<div><font color="#000412" face="gg sans, Noto Sans, Helvetica Neue, Helvetica, Arial, sans-serif"><span style="white-space-collapse: break-spaces;"><div style="">The Western biomedical validation framework includes pre-clinical and clinical methods such as laboratory assays, phytochemical and toxicity testing, animal studies, pharmacological profiling, and randomized controlled trials (RCTs) in humans. </div><div style="">Participatory ethnopharmacology is a framework for validating herbal plants with medicinal potential that documents how plants are prepared and used in communities, records healer and patient testimonies, and tracks health outcomes over time. In this framework, indigenous knowledge and community experience sit on equal footing with pharmacological testing, meaning that longstanding use and cultural validation can serve as sufficient evidence of safety and efficacy even without completing the full Western biomedical pipeline.</div></span></font></div>